When will my travel insurance coverage become effective? Published by Chris Harvey October 5, 2007 Cancellation coverage generally begins at 12:01 AM the day after you purchase a travel insurance policy. Most other benefits are effective on your departure date. Related articles: Can I get live assistance with a quote or purchase? Are there medical conditions that are not covered by travel insurance? Should I buy travel insurance if my trip is within the USA? Does TravelSafe cover my frequent flier miles? Do any policies cover trip cancellation/trip interruption as a result of work related reason or business commitments?